Data is king, and here are the best picks from the NFL betting model for Week 6 of the NFL season. Let’s explore. All lines come from our partner Oddsjam, and our specific picks are based off of Fanduel Sportsbook lines.

New York Giants @ Buffalo Bills (-14) (Vegas Total: 44.5) (Sun, 8:20 PM)

  • Model Expected Score: New York Giants 14.0 – Buffalo Bills 30.0
  • O/U Pick: Under | Model Rank: 9
  • Spread Pick: BUF -14 | Model Rank: 6
  • Moneyline Pick: Buffalo Bills

The Giants, despite some offensive struggles, will be looking to establish their offensive rhythm early against the Bills. Buffalo, with their dynamic offense, will be looking to exploit the Giants’ defensive vulnerabilities and put points on the board early and often.

Dallas Cowboys (-2) @ Los Angeles Chargers (Vegas Total: 50.5) (Mon, 8:15 PM)

  • Model Expected Score: Dallas Cowboys 25.5 – Los Angeles Chargers 23.5
  • O/U Pick: Under | Model Rank: 2
  • Spread Pick: DAL -2 | Model Rank: 13
  • Moneyline Pick: Dallas Cowboys

Both the Cowboys and Chargers have demonstrated the ability to put together sustained drives, and this game could come down to which team is able to make key defensive stops. Both teams have playmakers on offense that can change the game in a single play, and it will be crucial for both defenses to create turnovers and get off the field on third down

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Week 6 in the NFL is set to be a thrilling spectacle, offering a mix of high-stakes matchups and potential redemption arcs. Insights from Week 5 hint at pivotal strategies and standout player performances in the upcoming games. Fans can expect a blend of offensive showcases and defensive masterclasses throughout the week. Each matchup will challenge team resilience and spotlight emerging players. As we advance through the season, every game sharply influences the playoff trajectory, escalating the excitement and importance of each contest.

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